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The results further indicate that in addition to defining substrate specificity, the binding pocket orientates the bound catechol to minimize oxidative inactivation of the enzyme during catalysis.
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The "oxidative damage model" argues that this pattern serves to minimize oxidative damage to the tissues.
Since mitochondrial superoxide production is steeply dependent on Δp, proton leak pathways may exist to minimize oxidative damage by tempering Δp and mitochondrial superoxide production31,32,33.
Such shifts may help cells minimize oxidative damage caused by inflammatory cytokines in blood.
For example, circulating concentrations of carotenoids minimize oxidative stress [3], [4,], but see [5], and influence immune system activity [6].
In conclusion, creatine and PCr minimize oxidative stress in striatum to afford neuroprotection of dopaminergic neurons.
Chloroplasts subjected to high oxidative stress may develop plastoglobules, which help to minimize oxidative damage to the photosynthetic apparatus (Asada 2006; Møller et al. 2007).
For example, diffusion limited rate constants fit well for SOD's cellular function to scavenge superoxide to minimize oxidative damage.
On the one hand, induction of antioxidant enzymes protects beta-cells from oxidative damage and possible cell death, thus minimizing oxidative damage-related impairment of insulin secretion.
Our cocktail minimized oxidative stress in an ischemic kidney rat model while at the same time protecting the global parenchymal function during extended periods of ischemia.
Such negative feedback could protect neurons from excitotoxicity by minimizing oxidative stress.
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