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The ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients with Heart Failure) examines the effect of aliskiren on CV mortality and hospitalization in patients with chronic HF, whereas the ASTRONAUT (Aliskiren Trial on Acute Heart Failure Outcomes) evaluates aliskiren in patients stabilized after acute HF [ 196].
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To minimize outcome misclassification, the present study used CAG to confirm the diagnosis of obstructive CAD.
Behavioural data in healthy participants indicate consistent preference for options that minimize outcome variance (Kahneman and Tversky, 1984; Sanfey et al., 2003).
To minimize outcome measurement bias, all measurements collected pre- and post-intervention cannot be influenced by therapists providing the intervention nor by the study researcher.
Increased measurement frequency, higher target glycaemic bands, conservative insulin dosing and modulation of carbohydrate nutrition should be considered to safely minimize outcome glycaemic variability and reduce the risk of hypoglycaemia.
Overall this will minimize undesired outcomes and enhance long-term efficacy of the treatment.
o Something has to give when a company goes public in a moody market, but a smart startup can minimize negative outcomes by carefully calibrating the number of shares in an offering.
System optimization denotes a process through which an optimal solution naturally emerges from a set of alternatives to maximize favorable and minimize unfavorable outcomes [17] [22].
Ultimately, the concept of risk is applied to minimize adverse outcomes for a population [ 50].
Early clinical suspicion and implementation of appropriate antimicrobial therapy are critical to minimize adverse outcomes.
Early clinical suspicion and implementation of appropriate antimicrobial therapy are critical to minimize adverse outcomes [ 6– 8].
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