Sentence examples for minimize off from inspiring English sources

Given an input gene set, the algorithm selects drug combinations that maximize on target effects and minimize off target effects Literature support [63] Various Systems analysis of Drug Combinations Drugs with similar therapeutic effects cluster together in a network of successful drug combinations produced using the Drug Combination Database [59].

Two distinct dsRNAs were used in these experiments to minimize off target effects.

Nanotechnology offers the potential to improve drug solubility and stability, prolong drug half-lives in plasma, minimize off target effects, and concentrate drugs at a target site.

Necessary measures should be taken to minimize off-axis forces like reduction in occlusal table and cusp inclines.

Treatment conditions were designed to encourage visitors to stay on marked trails and minimize off-trail travel.

Development of innovative strategies that improve NUE and minimize off-field losses is crucial to sustaining cereal-based farming.

A comprehensive understanding of the post application fate of fertilizers is essential for the development of best management practices that aim to minimize off-site transport and maximize nutrient use efficiency.

While the current whole-genome sequencing has indicated that gene editing mediated by well-designed sgRNA and TALEN leads to minimal mutational load at global level (Hsu et al. 2013; Smith et al. 2014; Suzuki et al. 2014; Veres et al. 2014), precautions need to be taken to minimize off-targets caused by poor sgRNA and TALE design.

The implemented monitoring procedures and diagnostic facilities have the following results: prevent key components damages, extend critical components life-time, improve overall system performance and reliability, minimize off-line analysis effort and maintenance costs, allow remote plant check, diagnosis and evaluation.

Extensive efforts in computational biology have been directed toward the design of successful dsRNA reagents that maximize gene knockdown but minimize "off-target" effects.

Such an approach to designing experiments would minimize off-target effects of evolved Flp variants.