First, given that most human regulatory sites act in a cell-type specific manner, it may be advantageous to keep them masked with nucleosomes unless they are in use, to minimize instances of inappropriate utilization and aberrant transcription from open chromatin.
We chose a length of channel connecting the chambers as well as a width of exit hole leading into this channel that would minimize instances of cross traffic.
This stringency is aimed at minimizing the instances of falsely mapped reads, i.e. of reads mapping to regions to which they do not belong.
GAs allow the use of different factors to establish the test orders by using a fitness function based on an aggregation of objectives to be minimized, for instance, a weighted average of number of operations and number of attributes.
Vaguely speaking, the learner tries to minimize the number of labeled instances used in the course of learning, relaying also on unlabelled instances in order to acquire the needed information whenever possible.
A technique called extended reach drilling, for instance, can minimize the number of drilling platforms, and narrow-width "green pipelines" can move oil with fewer ecological disruptions.
Proponents of the first story typically minimize their objections to such instances of public religiosity -- except for whatever case they are grappling with at the moment.
The problem of connecting seed nodes in a weighted network such that the weight of the resulting sub-network is minimized is an instance of the Steiner tree problem, which is known to be NP-complete (Karp, 1972).
Primary targets of such an analysis in our case are extracellular dopamine, which should be increased to counteract the motor symptoms of PD, and toxic species, which should be minimized, for instance by means of decreased production or increased degradation.
We will also incorporate constraints that minimize the number of resource instance migrations across applications.
For ecological niche modeling (ENM) analyses, occurrence locations were considered only once, with no weighting to account for multiple cases at single locations, thus minimizing potential confounding attributable to (rare) instances of person-to-person transmission.
