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62 Another mutant-dedicated algorithm is regulatory on/off minimization (ROOM), which computes the minimal flux deviation from the wild-type flux distribution.
Predictions of mutant strain behavior in the past have been based on steady state theories such as flux balance analysis (FBA), minimization of metabolic adjustment (MOMA), and regulatory on/off minimization (ROOM).
Shlomi et al. applied regulatory on/off minimization (ROOM) to determine minimum number of changes between the mutant strain and the original strain [ 18].
Towards this end, a variety of tools/algorithms are available [ 14], including flux balance analysis (FBA) [ 15, 16], minimization of metabolic adjustments (MOMA) [ 17], regulatory on-off minimization (ROOM) [ 18] and metabolic control analysis (MCA) [ 19, 20].
Whereas, some algorithms based on the aforementioned methods can be used to identify such targets including minimization of metabolic adjustment (MoMA) [ 41], regulatory on/off minimization (ROOM) [ 42], OptKnock [ 43], OptStrain [ 44], OptReg [ 45], and OptGene [ 46].
Based on the hypothesis that fluxes in metabolic networks, altered by removal of a reaction, undergo a minimal redistribution compared to those of the wild type, minimization of metabolic adjustment (MOMA) [ 21] and regulatory on/off minimization (ROOM) [ 22] have been devised as two contending alternatives for analysis of perturbed metabolic network models.
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Data minimization: Minimize the information I am required to provide and share with others.
The computational results demonstrate that simultaneous minimization of energy and room temperature ramp rate is more beneficial than minimization of energy only.
In the wake of Trump's rapey comments to Billy Bush and his gross minimization of sexual assault as "locker room talk," men who spend time in actual locker rooms began speaking out about how unacceptable and abnormal such conversations are; thus, this photo was born.
A model for minimization of HVAC energy consumption and room temperature ramp rate is presented.
By weighing the field strengths with the room's ESL, the exposure minimization algorithm advances current methods by enabling minimization of specific rooms that are sensitive to a higher exposure.
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