And the principles of purpose limitation and data minimization need to be addressed at the soonest possible time to balance the benefits for businesses and researchers against God-given constitutionally protected individual privacy rights.
I suggest that optimization by means of general minimization techniques needs to be supplemented by a theoretical understanding of the SFM least-squares error surface.
If appropriately designed and powered clinical studies demonstrate equivalent effectiveness between a biosimilar and the comparator, then a cost-minimization analysis needs to be carried out and the least expensive medicine is chosen.
30 If clinical studies demonstrate an equal effectiveness profile of a biosimilar and the comparator, then a cost-minimization analysis needs to be carried out and the least expensive medicine is chosen.
During the minimization, the cost functional J needs to be evaluated only on Ω i, j, k m, defined as Ω i, j, k m : = [ i − 1 2 m, i + 1 2 m ] × [ j − 1 2 m, j + 1 2 m ] × [ k − 1 2 m, k + 1 2 m ], which is the support of Φ i, j, k m.
To obtain the solution that satisfies this minimization criterion, the nonlinear LS problem needs to be solved using the Gauss Newton method, which is a recursive algorithm used to solve nonlinear LS problems[23].
There are a few kinks here and there, and it sorely needs to add a few minimization options so that you can hide the toolbar when you're not managing your tasks, but overall the UI is terrific, as is speed.
Instead, the range profile at each employed antenna location first needs to be reconstructed through l1 norm minimization using the reduced frequency set [28].
In addition to the exclusion and minimization of local experience and perspective, the humanitarian logic itself needs to be examined: structuring many responses is a "photo op".
For men, the extent of risk minimization (the belief that men are not susceptible to reproductive hazards) needs to be determined.
