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Crash outcome data were collected from four administrative databases, thereby minimising potential biases associated with loss to follow-up and self-reports.
Using a large cohort of black and white male US veterans with a relatively homogeneous socio-economic background, we were able to examine medically diagnosed major groups of immune-related conditions and specific immune-related conditions while minimising potential biases associated with the case control study design.
Minimising potential biases, it included diverse regions, employed an appropriate mix of cluster-sampling and simple random sampling, applied ICHD-II diagnostic criteria [25] and had a very high participating proportion (99.8%).
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RCT is a design with stringent criteria for selecting participants and a strict compliance to the study protocol, minimising potential bias.
Nevertheless, we have followed up more than 90% of the UK cohort, thus minimising potential bias, and a statistically significant association between maternal 2009/H1N1 infection and preterm birth remains.
To help minimise potential biases we used an incident user design.
We minimised potential biases in the review process by adhering to Cochrane guidelines (Higgins 2011).
In particular, comorbidity-specific analysis at hospital level is encouraged to minimise potential biases reported elsewhere.
Although we have taken counter measures to minimise potential biases, these cannot be completely excluded.
Concerning the former, great care was taken to minimise potential biases in the conduction of this study.
In order to minimise potential biases induced by sporadically missing covariates (≤5%), we used the population average as substitute.
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