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Systematic reviews of randomized trials provide valuable evidence on the effectiveness of healthcare interventions, maximising power, minimising bias and avoiding undue emphasis on the results of individual studies.
In the interest of minimising bias and obtaining reliable estimates from a valid model, we subsequently opted for a propensity score matching strategy.
Data were extracted on the methodological domains relevant to minimising bias and random error in the analysis of trials by using the Cochrane methods for assessing risk of bias 18 and GRADE methods.
Importantly, the impact of this approach on data quality is unknown even though it may challenge two important principles for survey researchers: the maintenance of scientific rigour by minimising bias; and the duty to uphold the principle of fully informed consent.
Thirdly, SQUIRE now explicitly specifies elements of study design that make it possible to assess both whether improvement interventions work (by minimising bias and confounding) and why interventions are or are not effective (by identifying the effects of context and identifying mechanisms of change).
Continuing follow-up in a trial that has been stopped early has the advantages of minimising bias and obtaining more data on adverse events.
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We highlight aspects of trial design, conduct, and reporting that should be taken into account to minimise bias and improve quality.
The inclusion of a sham neurosurgical arm will be guided in part by the objectives of the clinical study (preliminary safety, optimisation, and feasibility vs preliminary efficacy vs confirmatory efficacy) and the need to minimise bias and confounds.
This approach was prospectively chosen to minimise bias and support face validity of the qualitative analysis.
The blinding of students to group allocations will hopefully minimise bias and preconceptions about virtual patients.
Consecutive recruitment is important to minimise bias and give a better reflection of the population.
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minimising age and
minimising mechanism and
minimising exposure and
minimising overinflation and
minimising energy and
minimising site and
minimising work and
minimising compliance and
minimising phototoxicity and
minimising tracking and
minimising maturity and
minimising volume and
minimising start and
minimising discretion and
minimising toxicity and
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