Detailed natural history models of breast cancer progression provide an opportunity to evaluate modification to screening programmes to identify optimal screening scenarios while minimising screening's negative effects, such as unnecessary biopsies following false positive tests and treatment of indolent cancers (Kobrunner et al, 2011).
This problem has been minimised by screening donors, but not yet eliminated (Desai and Neuberger, 2014).
Like all systematic reviews, the search may not identify all relevant literature; this will be minimised by screening reference lists of all included papers for additional literature.
Clinicians gave prospective participants brief information about the study, and in order to minimise risk, screened them for signs of relapse and suicidal thoughts/intent.
P18, Mid SES, Girl Most of the mothers interviewed felt that minimising screen-viewing was sensible and feasible, and some acknowledged adverse effects of screen-viewing for their child.
P13, Mid SES, Boy Although the majority of mothers felt that minimising screen-viewing was appropriate, they also felt that their child currently had acceptable levels of screen-viewing and no reduction was necessary.
The right environment involves normalising screening by offering a chlamydia screen to all 15-24 year olds at every interaction with staff, offering screening with a non-judgemental attitude and minimising barriers to screening such as embarrassment.
Furthermore, the lag period of 2 years might minimise the screening effect and the selection bias.
All participants were requested to refrain from heavy physical activity 24 h before screening to minimise the effect of fluctuations in hydration status on body composition measurements.
The analysis was carried out after excluding individuals diagnosed with PC within 5 years of screening to minimise confounding due to the possible effects of early disease affecting cholesterol [ 27].
