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Although these studies all suggest that T cells might be minimally tolerable to CRISPR/Cas9-induced off-target mutagenesis, non-biased strategies combined with deep sequencing for off-target detections should be applied to the selected target gRNA used in the clinical trials.
For example, 'acceptable' or 'normal' may have been interpreted as the health needed to live a decent life, the health needed to live a minimally tolerable life, some average indication of actual health at older ages or the health needed to maintain one's standard or aspiration of life.
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To adequately resolve these changes, the maximally tolerable noise level was chosen to be one third of Δ I, yielding a minimally required SNR min = 20 log 10 ((3 I 0 ) Δ I ).
This approach was tolerable with minimal toxicity.
However, as abiraterone is well tolerated and there is an appropriate and minimally invasive measure of efficacy against which to titrate the dose, this degree of variability is tolerable and should not limit clinical utility.
Minimally processed.
Legoland had been tolerable.
That much was tolerable.
Still, adequate is tolerable.
NOISE LEVEL -- Tolerable.
He was minimally conscious.
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CEO of Professional Science Editing for Scientists @ prosciediting.com