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Bcl-2, which varied minimally in normal tissue, did not show any trend across compartments or evidence for field effects.
Figure 6c shows that the cell viability was greatly reduced by SNIPER TACC3 -1 and -2 in human cancer cells but minimally in normal human fibroblasts.
Our main interest in this protein, however, is that it represents a useful tumour antigen in that it is expressed strongly at the cell surface in RCC tumours and minimally in normal tissues.
In the present study, we have demonstrated that the MRP3 gene is expressed both at the mRNA level and the protein level in high-grade gliomas, but minimally in normal brain tissue.
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To that end, we designed our approach to prioritize molecules that were minimally expressed in normal thyroid and highly expressed in PTC.
Such profiles were assumed to indicate potential target candidates, specific for a particular cancer lineage and minimally expressed in normal tissues (P5, RIT1).
These data suggest that Myog is minimally expressed in normal adult muscle, but may be upregulated after long periods of exercise proportional to the amount of running performed.
By semi-quantitative RT-PCR, we showed that the CSNK2A1P gene is also over-expressed in three NSCLC lines: H1299, H322, and A549, but minimally expressed in normal cells and two lung cancer cell lines H1650 and H460 (Fig. 1A).
We focused on the CSNK2A1P gene because we initially found it was minimally expressed in normal cells, but was predominantly expressed in several types of human cancer cell lines and tumor tissues, including the human T cell leukemia cell line Jurkat, which is known for its high CK2 activity.
We found that Pttg2 is minimally expressed in normal cells.
We observed that MMP-14 is minimally expressed in normal colonic mucosal cells.
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