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Some authors have searched for uniform measures for minimally important changes.
The proportion of patients meeting minimally important changes (MICs) in individual PRO scores was determined using published recommendations where available.
For assessing minimally important changes, anchor-based methods are preferred, as they include a definition of what is minimally important.
Some distribution-based methods to assess MIC have been more focussed on minimally detectable changes than on minimally important changes.
Several methods to determine minimally important changes (MICs) have been proposed which can broadly be divided in distribution-based and anchor-based methods.
Moreover, it becomes possible to judge whether the minimally detectable change of a measurement instrument is sufficiently small to detect minimally important changes.
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Trials can be designed so that the minimal detectable change, is less than the threshold of minimally important change ((MIC) i.e., a magnitude of change that may be considered patient-important).
[ 7] Thresholds of minimally important change (MIC) are often used to judge the clinical importance of between-group mean differences.
Preliminary thresholds for minimally important change should be further refined with additional interventional research.
Determining "minimally important change" (MIC) facilitates the interpretation of change scores on multi-item instruments.
Patients have their individual minimal important changes (iMICs) as their personal benchmarks to determine whether a perceived health-related quality of life (HRQOL) change constitutes a (minimally) important change for them.
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