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Use of corticosteroids in patients with diabetes and COPD should be accompanied by regular review to ensure that minimally effective doses are used, efficacy of treatment, and close monitoring of blood glucose control.
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It should be remembered that to be commercially viable drugs need to balance effectiveness with safety and there is little incentive to find the minimally effective dose.
The focus on time may obscure the more fundamental fact that we have little idea about what constitutes a minimally effective dose of psychotherapy.
Varying doses of UFH were tested to determine the minimally effective dose.
The ergot dose should be carefully selected as the minimally effective dose.
"Although we expect ultimate approval, a delay would not be surprising given tolerability data and questions on minimally effective dosing of the drug," she added.
Claim your minimally effective dose of self-care, every day, that tips the scales away from resentment.
The response to HOCl was found to be dose-related; the minimally effective dose was 100 mg/L.
Dose-response studies revealed that 0.4 micrograms gastrin mouse-1 day-1 appeared to be the minimally effective dose.
The translation of the minimally effective dose in cell studies into large-animal models is difficult (Rölfing et al. 2013).
Re-evaluating the need for a long-term corticosteroid therapy or using it at a minimally effective dose is warranted.
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