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The terminology can be confusing, with several terms differing only slightly in definition (e.g. minimal clinically important difference, clinically important difference, minimally detectable difference, subjectively significant difference).
Minimally important difference (MID) values were estimated via anchor based method, while minimally detectable difference (MDC) figures were calculated by distribution based method.
As a lay interpretation, the "response threshold" calculated as proposed can be assimilated to the minimally detectable difference, while the use of an external anchor would have configured a clinically minimal important difference.
For the six measures on which there was a statistically significant benefit for the active medication, four of the effect sizes (glucose control, weight control, appetite control, and treatment satisfaction) met the one-half SD criterion for a "minimally detectable difference" (21), the criterion representing a "moderate" effect (22).
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Further, the minimal detectable difference of a developed model is often not reported.
The minimal detectable difference in lung tumor multiplicity for the current study was 37%.
The minimal detectable difference is 0.64.
These figures were thought as relevant minimal detectable differences.
We considered a 0.5 SD difference on the PSWQ-A (3.35 units) and the HAM-A (3.5 units) in the post-intervention means as the minimally important detectable difference.
Our sample size calculation was based on the RDQ index as the primary endpoint with a minimally detectable effect size determined as a difference of 0.4 standard deviations (SD) based on published data [ 68, 77, 78].
We believe that the confusion about MIC will decrease if the distinction between minimally detectable and minimal important change is appreciated and acknowledged.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com