We believe that the confusion about MIC will decrease if the distinction between minimally detectable and minimal important change is appreciated and acknowledged.
Thus, this criterion of 0.5 SD may be considered a threshold of detection and corresponds more to minimally detectable change than to minimally important change.
The terminology can be confusing, with several terms differing only slightly in definition (e.g. minimal clinically important difference, clinically important difference, minimally detectable difference, subjectively significant difference).
The change patients undergo in therapy should not only be minimally detectable [ 22 ], but rather be minimal clinically important.
The results of the minimally detectable change test suggest that the APS20 should decrease by at least 0.6 points or 12 item responses by one grade, before any improvement beyond reproducibility noise can be detected.
Moreover, it becomes possible to judge whether the minimally detectable change of a measurement instrument is sufficiently small to detect minimally important changes.
Appreciating the distinction, it becomes possible to judge whether the minimally detectable change of a measurement instrument is sufficiently small to detect minimally important changes.
Two other putative genes encoding collagen type IV (col4 6 and col4 7) exist within the planarian genome, but were minimally detectable in RNA-sequencing data and were not considered high confidence collagen-encoding genes (Supplementary Data 1).
However, little is known about the reproducibility of network properties derived from whole brain tractography data, which has important consequences for minimally detectable abnormalities or changes over time.
Decreased focus or study size, lower SPECT resolution, absence of scatter, and attenuation correction resulted in an increase in minimally detectable activation.
