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At the same time, the biological replicates of each stage clustered together, suggesting minimal variance between replicates.
There was minimal variance between individuals with respect to the relative ratio of PBMCs over time (Table 1).
Although the fetal liver samples were obtained from mid-gestation spontaneous miscarriages, the expression and methylation results we obtained showed minimal variance between samples.
In fact the minimal variance between physicians indicated no noticeable heterogeneity between physicians (τ2 = 0, I2 = 0), resulting in same estimates from E-1 and E-2.
Further experiments indicated that performance peaks around 25% of the feature space with minimal variance between the folds (data not shown).
Population and replicate, originally included as random effects in this analysis, were removed since there was very minimal variance between groups (replicate variance = 1.7×10−14, population variance = 1.7×10−2) (Starkweather, 2010).
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We defined the excess variance as the difference between the measured variance and this fitted minimal variance.
DOI: http://dx.doi.org/10.7554/eLife.05856.008 10.7554/eLiFigure56.009 Figure 1 figure supplement 6. Mean log-fluorescence (horizontal axis) and excess noise levels (vertical axis), that is, the difference between variance of log-fluorescence levels and the minimal variance at the corresponding mean, for all native (blue dots) and synthetic (red dots) promoters.
There are two objectives for estimating the weights: to obtain minimal variance of estimation and to constrain the minimal variance objective.
(Minimal variance) Use Algorithm 2.2 to obtain the segmentation results for the smooth image u.
Each cluster contains a highly similar group of samples with minimal variance.
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