Sentence examples for minimal toxic effects from inspiring English sources
Development of therapies that specifically target the AMPK HNF4α WNT signal cascade would probably represent effective approaches with minimal toxic effects for the management of gastric cancer.
No obvious signs of necrosis or inflammation were observed, confirming that Sgc8-FSNPs show minimal toxic effects (Fig. 6b).
However, when intercalated within a lipid membrane, the hydrophobic drug can be administered to a patient with minimal toxic effects.
Much emphasis has been placed on discovering new compounds that target tumour cells more efficiently and selectively with minimal toxic effects on normal cells.
Moreover, the combination treatment showed minimal toxic effects in normal animals (Supplementary Figures 7b g).
While BSO alone produced minimal toxic effects, combinations with melphalan occasionally resulted in severe myelosuppression.
In principle, serial transfection of small ncRNAs together with protein-encoding mRNAs can effectively alter cell fate with minimal toxic effect and alterations in genomic DNA.
This study suggested low toxicity, and a NOAEL of no less than 1.88 mg/m3 was recorded for the body weights, bronchoalveolar lavage fluid inflammatory markers and blood biochemical parameters [298] Graphene [0.68 ± 0.14 3.86 ± mg m−3, 6 h/day and 5 days a week] Male Sprague Dawley rats Minimal toxic effect at the concentrations and time points in this study [296].
Analogous to the EMEA recommendations, extended single-dose toxicity studies in both genders of a single mammalian species to establish a dose inducing a minimal toxic effect or a safety margin are considered sufficient to support a human microdose study if justified by in vitro data.
The enhanced ability of relatively low doses of amifostine to inhibit spontaneous metastases formation suggests that effective antimetastatic therapies with amifostine can be designed with minimal toxic side effects.
The IC10 calculated by SPSS 13.0 was 19.89 µg/mL, and was considered to be a safe dose for VK2 cells with minimal toxic side effects, and was selected for further experiments.
