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In the present study, a dry powder inhaler system of IK312548 was designed for inhalation therapy with minimal systemic side effects, the physicochemical properties of which were also evaluated with a focus on morphology, particle size distribution, inhalation performance, and peptide stability.
There is an urgent need for novel polymeric carriers that can selectively deliver a large dose of chemotherapeutic agents into hepatic cancer cells to achieve high therapeutic activity with minimal systemic side effects.
Physical energy-induced chemical surgery, a technique that induces antitumor effects by delivering a drug that exerts a therapeutic effect in response to physical energy and irradiating the diseased part with the corresponding physical energy, is a useful method to treat cancers with minimal systemic side effects.
The technique was widely adopted and achieved symptomatic relief with minimal systemic side effects [ 5].
There are minimal systemic side effects (hypertension, first-degree atrioventricular block, coughing, nausea).
Intrathecal baclofen delivery via an implanted pump is a safe, effective and reversible treatment for spasticity, with minimal systemic side effects.
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Capecitabine has minimal systemic myelosuppressive side-effects because it is a nontoxic prodrug that is only metabolized by carboxylesterase and cytidine deaminase within the liver and thymidine phosphorylase in the tumor 21.
Adjuvants for new-generation vaccines are designed as precision instruments able to trigger appropriate immunological target molecules with minimal local or systemic side reactions.
Ideally, a phosphate binder should effectively bind dietary phosphate regardless of pH, have minimal systemic absorption, few side effects, good palatability, a low pill burden and be available at a low cost [ 53].
Lymphokine-activated killer (LAK) cells generated from PBMC by co-culture with IL-2 have been reported to selectively kill glioma cells in vitro and when placed into the resection cavity with minimal systemic or neurological side effects [ 38, 39].
There were minimal reports of any systemic side effects; specifically no symptoms of a flu-like illness or lymphadenopathy.
More suggestions(15)
minimal systemic toxicity
minimal systemic bias
minimal systemic disease
minimal systemic activity
minimal systemic absorption
minimal systemic escape
minimal systemic capillary
minimal systemic drug
minimal systemic anticoagulation
minimal systemic exposure
minimal gastrointestinal side
minimal systemic bioavailability
minimal transitory side
minimal systemic accumulation
minimal systemic heparinization
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