Sentence examples for minimal systemic effects from inspiring English sources
However, we did not consider local topical and ophthalmological drugs since they have minimal systemic effects, or antibiotics, given their lack of effect on the central nervous system.
Inhaled corticosteroids (IHCs) are the most effective medication to date for the management of persistent asthma with minimal systemic effects and have been shown to reduce the severity and incidence of asthma exacerbations.
The pharmacokinetics/pharmacodynamics data were used to identify model parameters that describe membrane insulin binding and glucose-insulin dynamics.Target exposure after IAM was similar to systemic full dose administration but with minimal systemic effects.
An important advantage of a nanotechnological approach, as compared with the administration of a free drug, is that the crucial requirements needed to reach the CNS while producing minimal systemic effects can be met by supporting parts of the engineered complex.
12 20 Lastly, mesalazine has minimal systemic effects and almost no adverse reactions.
Locally administered steroids have minimal systemic effects owing to the small dose administered and short duration of exposure [ 10].
Intrathecal baclofen delivery via an implanted pump is a safe, effective and reversible treatment for spasticity, with minimal systemic side effects.
In the present study, a dry powder inhaler system of IK312548 was designed for inhalation therapy with minimal systemic side effects, the physicochemical properties of which were also evaluated with a focus on morphology, particle size distribution, inhalation performance, and peptide stability.
The main advantage of posterior subtenon steroid injection is a prolonged effect due to a maximal local concentration of the drug that causes minimal systemic side effects [ 20].
Intralesional corticosteroids are one preferred method for treating small localized infantile hemangiomas because of efficacy in halting proliferation and minimal systemic side effects.
There is an urgent need for novel polymeric carriers that can selectively deliver a large dose of chemotherapeutic agents into hepatic cancer cells to achieve high therapeutic activity with minimal systemic side effects.
