Sentence examples for minimal systemic accumulation from inspiring English sources

Minimal systemic accumulation was evident by an accumulation index of approximately 1.5-fold, and steady-state was reached by the end of the third dosing interval.

The ideal sedative and analgesic regimen will provide adequate sedation and pain control, be of rapid onset of action and allow rapid recovery after discontinuation, have minimal systemic accumulation, and carry minimal adverse effects, without increasing overall health care costs (which is a challenge in the development of a novel drug or application).

Furthermore, Krueger et al showed that tacrolimus ointment is associated with minimal systemic absorption and no evidence of systemic accumulation in patients with moderate to severe AD. 41 One of the recent topics on topical tacrolimus is that proactive intermittent low-dose application can control acute disease and prevent exacerbations.

Furthermore, in children, bortezomib is associated with minimal systemic toxicity [24].

Additionally, these particles have been demonstrated to show minimal systemic toxicity [11,12].

Bone-targeted radiation therapy is an attractive strategy for addressing bone disease with minimal systemic toxicity.

One key concept for reducing systemic side effects via pulmonary drug delivery is to select drug candidates with prolonged pulmonary efficacy and minimal systemic exposure [7, 9].

No pulmonary or systemic accumulation was observed over three days in piglets with normal kidneys [5, 38].

The toxicological data for chloroxylenol indicate lack of genotoxicity, no evidence of carcinogenicity, and minimal systemic toxicity.

In toxicological studies, after 1 month repeat application in minipigs minor dermal irritation and minimal systemic exposure were observed.

Our efforts resulted in the identification of compound 4a which significantly reduced food intake with minimal systemic exposure in rodents.