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We first tested the minimal structural requirement for PBDE activity toward RyR1 using [H]Ry binding analysis to microsomes.
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Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
In addition, these theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with this biological activity.
In addition, these theoretical calculations permit us to determine the minimal structural requirements to produce the antifungal response and may provide a guide for the design of compounds with this biological activity.
Once a lead compound (whether from nature or from a peptide library prepared by combinatorial chemistry) has been defined based on the desired agonist activity, it is often desirable to determine the minimal structural requirements for bioactivity.
In order to design novel compounds able to selectively inhibit the osteoclast V-ATPase we firstly identified the minimal structural requirements of bafilomycin A1, a macrolide antibiotic which potently inhibits all V-ATPases.
Starting from the reported tetrapeptide hepsin inhibitor Ac-KQLR-ketothiazole (kt) (1), we investigated the minimal structural requirements for hepsin inhibitory activity by truncating amino acids at the N-terminus.
A surprising number of small businesses operate either as sole proprietorships with no corporate structure that shields the business owner's personal assets or under a corporate shell that fails to comply with minimal structural requirements.
Interestingly, in an effort to elucidate the minimal structural requirements for checkpoint activation, Xenopus egg extracts were utilized to demonstrate that the length of single stranded DNA between the free ends of primed DNA, influenced the degree of Chk1 phosphorylation [39].
A final document of 104 indicators were decided upon that describe the minimal structural requirements for EaCC in low-income countries (available in the Additional file 2).
In rare cases even oligosaccharides as short as tetra- or even disaccharides have been shown to possess the minimal structural requirements for raising functional antibodies.
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