Thus, an RNAi model in which the cells have higher supply of siRNA at the time of onset of apoptosis is likely to persist for a few days during apoptosis, whereas one with a minimal steady-state supply of siRNA is likely to be abrogated rapidly due to rapid exhaustion of its siRNA.
Notably, this concentration is substantially lower than that reported as the minimal steady-state concentration in clinical trials (Ranson et al, 2002).
In accordance with the minimal steady-state concentration reported in the clinical trial (264 ng ml−1; 0.59 μ M), PC9 and A549 seemed to be sensitive to gefitinib.
EFMs are minimal, feasible, steady state pathways through a metabolic network.
Based on the number of submissions to ONEShare, uptake of the tool by researchers has been minimal but steady.
OK cells express an endogenous NaPi-2a transporter, NaPi-4 [ 24], which is usually expressed in the brush-border membrane, and intracellular expression is minimal under steady-state conditions).
Compound G281-1564 in particular could inhibit VEEV replication at low μM concentration, while showing minimal toxicity, with steady state and dynamic quantitative microscopic measurements confirming its ability to inhibit CP nuclear import.
The photographs were evaluated and compared by two independent dermatologists using the quartile grading scale: 1 = minimal improvement or steady state (0 25%), 2 = moderate improvement (26 50%), 3 = marked improvement (51 75%), and 4 = excellent improvement (76 100%).
The baby-machine system, which produces newborn Escherichia coli cells from cultures immobilized on a membrane, was developed many years ago in an attempt to attain optimal synchrony with minimal disturbance of steady-state growth.
