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We have used the cyclin binding motif (CBM) present in the tumor suppressor proteins p21WAF1 and p27KIP1 as a template to optimize the minimal sequence necessary for CDK2/CA inhibition.
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The minimal 3' sequences necessary for barrier activity were determined by 3' truncation of PD1 cDNAintergenic intergenic sequence to the poly A addition site (PD1 cDNAint1-2/PolyA) (Figure 3A).
Next, we delineated the minimal IncA sequence necessary to retain the inhibitory function.
Next, we determined a minimal consensus sequence necessary for TEL2 phosphopeptide interaction with the PIH-N domain.
Here, we focus on refining the minimal XIST sequence necessary for cis-regulated silencing, independent of the developmental signals that establish mono-allelic XIST expression in females.
Two adjacent nucleotides (A and T) are the minimal essential sequence necessary to expand the host range of AcMNPV (Kamita and Maeda 1997).
This study was designed to identify monocyclic peptide fragments of the hAGRP 86 132) to determine the minimal active monocyclic sequence necessary for antagonism at the MC3R.
This sequence is known to be the minimal sequence required for an efficient RNA replication.
Let $f_1, \ldots, f_ r \in I$ be a minimal sequence of generators.
This HCR system has minimal sequence constraints, allowing reconfiguration for the detection of arbitrary target sequences.
Therefore, to determine the minimal virus-specific 5'NTR sequences necessary for GBV-B RNA replication, we constructed GBV-B/HCV chimeras in which translation was placed under the control of an intact HCV IRES, while segments of GBV-B 5'NTR potentially involved in genome replication (domains I-II or I-II-III) were retained upstream.
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