Exact(2)
Originally identified through conservation of a minimal sequence motif from Drosophila to mammals, PAS domains function as sensors of chemicals and light and act as oligomerization nodes.
We find two predominant sharp peaks on either side of the 19-bp CTCF motif that are separated by 19 bp, indicating that on average for each of our immunoprecipitated fragments, MNase has chewed back to one side of the minimal sequence motif.
Similar(58)
As a result we felt that there is a definite requirement to find prediction methods for large scale global profiling of natural substrates of the human proteases and decided to test the potential of minimal sequence motifs for this purpose.
10.7554/eLife.09225.005 Figure 3. High-resolution X-ChIP-seq provides base-pair resolution of the minimal CTCF sequence motif.
Analysis of the JP2 primary sequence did not identify any of these motifs; however, there is often minimal sequence homology between individual PH motifs, although the 3D structures are conserved, making the presence of phosphoinositide-binding domains difficult to predict.
We run Weeder under the following settings: the species code is HS; the minimal sequence percentage on which the motif has to appear is 5 (to increase sensitivity); and the top 20 000 (sufficiently large) motifs are reported.
Previous studies have shown that the INNIXW motif is the minimal sequence required for peptide activity.
The MKKK sequence is essential for the internalization by raft-dependent endocytosis [ 99] and the RMKKK motif is the minimal sequence required for its nuclear localization [ 100].
They also determined that the minimal sequence required for binding between the DLG motif and the Kelch domain is Ac-WRGDIDL-OH (Fig. 5).
They determined that the minimal sequence required for binding between the ETGE motif and the Kelch domain is the seven-amino-acid sequence Ac-DEETGEF-OH and that the optimal sequence was Ac-DPETGEL-OH.
Other than this motif, the Cas6 proteins exhibit minimal sequence similarity.
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