These peptides have similar sequences to the cyclotides Viphi F and Viphi G), indicating that even minimal sequence changes can significantly influence the bioactivity.
Thus, the polymorphic region can either be very diverse, or bear only minimal sequence changes generating only a single discriminating peak.
In mammalian and other vertebrate cells, the elimination of double-strand breaks with minimal nucleotide sequence change involves the spatiotemporal orchestration of a seemingly endless number of proteins ranging in their action from the nucleotide level to nucleosome organization and chromosome architecture.
The most effective peptide variants (A5 and F1A5) have minimal amino acid sequence changes relative to the AH1 peptide.
Each sequence changes the distribution chain".
This study does not employ dynamic update of the background model, since the tested video sequences contain minimal ambient lighting change, and for such sequences a one-time construction of a static background model provides reasonable performance.
The Ostrinia FARs are very essential to determine the final pheromone compositions [ 22], minimal changes in sequence can cause the pheromone component ratio to shift dramatically [ 23].
The ability to retain activity while reducing immunogenicity is a key element for success of targeted therapies and is more likely achieved for non-human proteins by mutations in immunogenic epitopes, since this requires minimal change in sequence and structure.
Partial sequencing of SLEV isolates from southeastern California has indicated minimal genetic change during sequential years with SLEV activity but differences from isolates made after years with no virus detection (12, 23) and from strains sequenced from Central and South America (24).
Other common repeat sequence classes showed minimal fold changes, with a moderate reduction of H3K27me3 at L1 repeats and a slight increase of H3K27me3, Suz12, and Ring1B at SINE repeats.
