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Compound 6 (Cdk1/2 inhibitor III) was the most selective (18-fold) for PKN2 over PKN1 with only minimal selectivity over PKN3.
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High selectivity over FXa inhibition was achieved.
However, it lacked sufficient selectivity over mu-opioid receptor (10×).
The frequency selectivity over the entire bandwidth results correlated subcarrier.
BP and CHB selectivity over Ni2P/SBA-15 catalyst was changed slightly at 300 340 °C, and BP selectivity decreased apparently at 360 380 °C.
A-369508 shows >400-fold selectivity over D2L, >350-fold selectivity over 5-HT1A and >700 1000-fold selectivity over all other receptors tested.
However, at 200 µM of analyte, the sensor has >18-fold selectivity over ATP.
ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.
The compounds also showed excellent selectivity over human MRC5 cells.
(R)- 2 has modest selectivity over BRD4(1) [ KD=1.4 μ m (ITC)] and good selectivity over seven other phylogentically diverse BCPs.
These compounds have excellent selectivity over MMP-1 and MMP-9, but only moderate selectivity over MMP-2.
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