While gene expression in the young rats was approaching pre-fracture levels by six weeks after fracture, gene expression showed minimal return to normal in older rats.
In this case, however, it should be noted that mutating the NLS is just a way to increase the amount of TDP-43 production through its autoregulation process (6, 7) by increasing the amount of this protein that is made by the cell and exported to the cytoplasm with minimal return to the nucleus.
They rely on the taxpayer to underwrite their risk, yet they pay a minimal return back to the exchequer".
Another 20% of VC investments can be expected to fail or achieve minimal returns, with the remaining 60% returning an average 2.5 to three times invested capital.
Ticket sales (priced £5 to £8 per head) make minimal returns – especially as there's free entry on Tuesdays, a deliberate move to ensure it stays accessible to locals and students.
Large companies also want to put their cash stockpiles to work because they're getting minimal returns on them, said Oliver Pursche, president of Gary Goldberg Financial Services.
Meanwhile, taxpayer-controlled Royal Bank of Scotland had been one of the largest investors in Icelandic bank bonds, a position that has left it a non-priority claimant, expecting only minimal returns in its claims.
That was a huge burden for a sector already bruised by rising costs and minimal returns, with the country's economy growing at its slowest pace in 13 years in 2012 and data so far this year surprisingly negative.
Chan (1988) argued that the risk of winners and losers is changing over time and, when the risk factor is controlled, the reversal strategy can only produce minimal returns.
Upon stimulation onset, RPs (defined by eq. 18 in Methods section) increases rapidly to its maximal value then, after stimulation offset, gradually decreases to zero (Fig. 4A), while SP (defined by eq. 19) decreases rapidly to its minimal value then gradually returns to zero (Fig. 4B).
