While only a minimal response was observed with a tet concentration of 0.5 μg ml−1, maximal expression of TRAIL by Jurkat-TRAIL was reached at 2 μg ml−1.
An example of this is bortezomib (Velcade) for the treatment of relapsed multiple myeloma, where a "response rebate" scheme was established by the Department of Health so that patients who showed no or minimal response are taken off treatment and drug costs are refunded by the manufacturer.
The results are corrected to remove artifacts due to cytotoxicity and parameters such as concentration for half maximal activity, maximum efficacy, and minimal response are used to make activity calls based on algorithms for specific assay types and platforms (Judson et al. 2010).
It may feel as if you're denying yourself the chance to set things straight, but bear with it; withdrawing to minimal responses is the best approach.
Minimal responses were seen in patients with inactive disease and in non-IBD patients while the results from CD patients with active disease are summarized in Table 2. T-cell lines that reacted to MAP were detected in 5 of 7 (71%) patients in the CD group.
Many toxicological end points were investigated, but only minimal responses were observed.
Minimal responses were detected to our negative control (KLH), and responses to the positive control (PHA) did not differ significantly between patients or healthy controls.
