Extracellular vesicles (EVs) were used for mRNA-based HchrR6 gene delivery: EVs may cause minimal immune rejection, and mRNA may be superior to DNA for gene delivery.
Minimal artifact rejection was applied for the ERP (Figs. 2 and 4) and power analyses (Fig. 5) trials for which the maximal absolute value of the EEG signal in at least one of the central electrodes (C3, C4, and Cz) was higher than a given threshold (500 μV) were excluded from our analyses.
Among several mouse models, C57BL/6 mouse is clearly a better transplant recipient with only minimal immunological rejection of GFP.
Autologous bone represents the gold standard for bone replacement, because it offers minimal immunological rejection, complete histocompatibility, provides the best osteoconductive and osteoinductive properties, and is inexpensive and easy to obtain [ 55].
Lastly, in both the ex ovo and in ovo models, the chicken embryo presents minimal xenograft rejection since the embryo maintains immature, maternal B-cell populations incapable of full immune activity [ 32, 33].
We also demonstrated that the immunocompetent C57BL/6 mouse is a better transplant recipient as it shows only minimal immunological rejection of GFP, and GFP transgenic mice appear to be a are better quality cell source than the in vitro transfected ones due to their ability to circumvent the immune response to the vector.
Lee pioneered hand transplants and created a means of using minimal anti-rejection drugs for these procedures known now as the Pittsburgh Protocol.
As shown in Supplementary Fig. 32, both RB and acid fuchsin demonstrated minimal changes in rejection over this wide range of ionic strengths.
What's more, he has converted the full 2,500 acres to biodynamic production - that is, farming as close as possible to natural rhythms: no chemicals or routine medicines, absolute seasonality, minimal intervention and rejection of most of modern farming's technical wizardry.
