Exact(50)
Core promoters are minimal regions sufficient to direct accurate initiation of transcription and are crucial for regulation of gene expression.
Due to the low hierarchy architecture, the increased size of the minimal regions helps to reduce the runtime overhead.
The creation of lentiviral vectors with highly engineered EboZ envelopes improved the performance of the system and should also increase its safety since only minimal regions of the EboZ envelope, which lack the toxic domain, are used.
The large data set enabled refinement of minimal regions and identification of rare amplicons such as at 1p34 and 20q11.
The Nter-mHtt-responsive minimal regions also contained several GC-boxes, which are known to be potential Sp binding elements.
We performed further fine scale mapping with smaller deficiencies to define the minimal regions containing the lethal mutations.
Similar(10)
The minimal region of 1p35-36 was found to be deleted in more than 50% HCC patients.
A minimal region of 8p21-22 was found to be frequently deleted in HCC.
The minimal region of 1q21 was found to be amplified in more than 50% of HCC patients.
A useful method for pinpointing a minimal region of interest and potentially gene(s) is the occurrence of recurrent chromosome changes, and particularly recurrent chromosome breakpoints.
Using a plate-based, fluorescence polarization (FP) assay, we identified a minimal region of LZ4 that suppresses binding of HSF1 to the HSE.
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