Sentence examples for minimal region that from inspiring English sources

For example, on chromosome 20, the high-amplitude approach identified a small minimal region that was not evident from the low-amplitude analysis.

From these results, we conclude that the region from amino acids 49 to 101 is the minimal region that possessed the capacity to bind actin.

In order to identify the minimal region that was responsible for the observed chaperone-like function, we further expressed HA-tagged NTD125 and its deletion constructs (NTD93, NTD61, and NTD55) in KB cells and utilized the whole cell extract (WCE) for in vivo ELISA and IPP utilizing conformation specific antibodies (PAb1620/PAb240).

Moreover, the key amino acids within this minimal region that are directly in contact with the antibody can be further determined by point mutations as discussed below [ 8].

The extended conformation of OASF when coupled to ORAI1 may reflect a specific, intramolecular transition possibly exposing the minimal region, that is CAD/SOAR (Park et al, 2009; Yuan et al, 2009), essential for this interaction with and/or gating of the ORAI1 channel (Park et al, 2009).

By aligning the profiles of multiple genomes, patterns of gain and loss are revealed and minimal regions that potentially contain tumour suppressor genes and oncogenes can be identified.

While this analysis relies on the assumption that the effects of the loci are additive, whereas the observations could be explained by more complicated genetics, it allowed us to delimit minimal regions that should contain at least one gene underlying the trait difference.

To define the minimal genomic region that confers basic expression of the SPG4 gene, we tested the ability of different fragments of the genomic region upstream of the first ATG of the SPG4 gene to drive the expression of the luciferase gene in transiently transfected HeLa, HEK293 and SH-SY-5Y cells.

It has been previously demonstrated that the minimal region of Smo that is required for activity comprises amino acids 1 637 (35).

This work was based on the idea that identification of the minimal region of Smad6 that binds to Pellino-1 and delivery to the inner leaflet of the membrane would allow the minimal region to bind to Pellino-1 and disrupt Pellino-1-mediated signaling complexes, resulting in therapeutic effects for TLR4-related inflammatory diseases.

The location of these sites was based on the determination of the minimal region of loss that is defined by the occurrence of 'breakpoints' surrounding regions of frequent LOH.