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The minimal region required for X-chromosome inactivation contains the non-coding (nc) RNA gene XIST, which is expressed solely from the inactive X chromosome [ 2].
Collectively, these assays support the existence of a response element for unliganded GR within the Ch25h promoter "region 11" and that the minimal region required is between -375 and -225 bp.
Examples like these would help the scientists to look into the structural details and study what is the minimal region required for the desired activity and is safer at the same time.
This region (amino acids 907-1210 in HCV genotype 2a), mapped through truncation analyses, is the minimal region required for activity; NS2-3 cleactivitytivity occurs independently of NS3 protease activity (Fig. 1B) [1B].
The gene locus is split in two parts, phnGHIJKLM (the minimal region required for C-P bond cleavage, Dpo_1c08140 to Dpo_1c08080) and phnDEEC (phosphonic acid transporter region, Dpo_1c07910 to Dpo_1c07940), which are separated by 13 genes.
It was shown in [ 30] that the minimal region required for specific DNA binding includes the single zinc finger and two basic regions on either side of the ZF domain.
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We used heterologous multimerization via the VASP tetramerization domain (VTD) to further define the minimal regions required for Mto1 localization to different sites.
The boundaries of the rearrangements in these two samples mark a ∼72 kb minimal critical duplicated region required for ADLD, between chr5:126,102,443 and chr5:126,174,517 and includes the LMNB1 gene only (Fig. 1A).
We next sought to determine the minimal domain within the V3 region required for SU-CXCR4 interaction.
By using a truncated Pseudomonas syringae AvrRpt2 effector reporter devoid of type III signal sequences, we have localized the minimal region of AvrBs2 required for type III secretion in Xcv.
The minimal region of JIP1 required for interaction with VRK2 isoforms is located within residues 471 to 660 (Fig. 4E), and the interaction of this C-terminal construct GST-JIP1 (471-660) with VRK2B appeared to be stronger (Fig. 4E).
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