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A minimal region of 8p21-22 was found to be frequently deleted in HCC.
The minimal region of 1p35-36 was found to be deleted in more than 50% HCC patients.
The minimal region of 1q21 was found to be amplified in more than 50% of HCC patients.
Using a plate-based, fluorescence polarization (FP) assay, we identified a minimal region of LZ4 that suppresses binding of HSF1 to the HSE.
A minimal region of homology of 30 to 50 bases flanking the fragment to be inserted is all that is required for targeted mutagenesis.
A useful method for pinpointing a minimal region of interest and potentially gene(s) is the occurrence of recurrent chromosome changes, and particularly recurrent chromosome breakpoints.
We first sought to compare the minimal region of chromosomal gain at 19q12 across multiple tumor types.
For example, on chromosome 20, the high-amplitude approach identified a small minimal region that was not evident from the low-amplitude analysis.
To define the minimal region essential for α-cleavage, the generation of C1 was assessed in PrPC constructs bearing smaller deletions within the stretch 100 129.
The construct MUC1*1110, truncated after only forty-five (45) amino acids of the extracellular domain, may represent the minimal region of MUC1 necessary for its oncogenic function.
A minimal region, capable of activating Dpy2 splicing in vitro, was mapped to the first 90 nucleotides of exon 23 (Figure 1, D90).
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