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During the study, we also noted that a minimal fiber protrusion of 0.5 mm could be advantageous in a clinical setting.
We favor an anterior gastropexy approach instead to perform anti-reflux surgery and prevent recurrent protrusion and torsion of the incarcerated organ with minimal risk.
Anatomically, protrusion is a focal displacement of disc material with no or minimal disruption of the fibres of the overlying annulus fibrosus and intact posterior longitudinal ligament (Fig. 12).
In this minimal OC, TATA-DNA and TBP reside above the Pol II cleft between clamp and protrusion domains.
Meanwhile, the two different relative changes in Protrusion Index (relative change in side-chain mean PI upon complexation and relative change in minimal PI upon complexation) used in our method are also strong evidence of hot spots.
Third, relevant cell and tissue features were indistinguishable between controls and minimal nocodazole incubations, namely (i) cell diameter; (ii) the morphology of primary cilia, an interphase microtubule-dependent cell protrusion; (iii) the elongated bipolar morphology of APs; and (iv) the overall cytoarchitecture of the cortical wall as revealed by the pattern of microtubules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com