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The components of the minimal pathway maps.
The components of minimal pathway maps for each of the organisms are shown in Table 2.
The network of minimal pathway maps of E. coli is shown in Figure 4.
Figure 2B shows the same distribution of hits for the gene and minimal pathway assays.
These sets of autonomous pathway mapsγ were, in turn, used to determine the minimal pathway maps.
The minimal pathway maps were also compared with the KEGG pathway maps of Mycoplasma genitalium.
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The present approach may be used to study other metabolic networks and to design new minimal pathways.
Metabolic pathway analysis is the study of meaningful minimal pathways or routes of connected reactions in metabolic network models [ 1, 2].
The enumeration procedure is performed by the algorithm FindPath, which enumerates all the minimal pathways and does not output duplicate hyperpaths.
The chemicals that hit ≥ 20 of the minimal pathways with a 30-μM cutoff are fluazinam, mancozeb, maneb, metiram-zinc, and pyraclostrobin.
The conazoles and triazoles (many of which overlap) and pyrethroids show the broadest activity spectrum, with median number of pathway hits of around 10 of the 33 minimal pathways.
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