Sentence examples for minimal off from inspiring English sources
As our knowledge of PKC biology deepens, it is evident that specific isoenzyme inhibitors may be insufficient for a drug to have optimal efficacy and minimal off target effects [ 51].
The particles themselves did not induce any toxicity, and normal cells displayed minimal off-target effects.
Using a similar approach, Kleinstiver et al. made a quadruple amino acid substituted SpCas9 that retains high on-target activity with minimal off-target activity.
The MEMS mirror is mounted at 45° to the optical axis of the lens and the en-face scanner performs post-objective scanning with minimal off-axis aberrations.
Other potential advantages of microwave processing include; high energy densities, selective heating, improved control, environmental benefits and minimal off-gas generation.
Therefore, stimuli-responsive polymeric micelles for on demand drug delivery with minimal off-target effect has been developed and extensively investigated to assess their sensitivity.
The therapeutic manipulation of these pathogenic microRNAs necessitates novel, efficient delivery systems to facilitate microRNAs modulators targeting osteoclasts with minimal off-target effects.
NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.
This configuration often uses fiber prism assembly and MEMS mirror scanners with 45°, which can serve as an en-face scanner with the post-objective configuration for the minimal off-axis aberration.
Among them, several compounds showed good T-type calcium channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at 10 μM = 61.85 71.99, hERG channel IC50 = 1.57 ± 0.14 4.98 ± 0.36 μM).
Nanomedicine aims to advance cancer treatment through functional nanocarriers that delivers one or more therapeutics to cancer tissue and cells with minimal off-target effects and suitable release kinetics and dosages.
