Therefore, we adopted an orthogonal biological phenotypic screening approach to uncover candidate compounds: based on a potent cytotoxicity toward HCC-derived cell lines, and minimal toxicity toward normal liver cells.
Studies in human tissues showed minimal expression in normal liver and small bowel tissue; however, no CCAT1 expression was detected in many other human tissues tested.
The advantage of radioembolization is the ability to deliver high dose radiation to the tumour with minimal collateral damage to the normal liver parenchyma or surrounding tissues.
This comparison may be performed in either semiquantitative (i.e., normal liver echotexture, minimal, mild, moderate, and severe hyperechogenicity [ 5]) or quantitative modality (i.e., hepatorenal index [ 38]).
In an analysis of 52 HCC tumors from patients infected with hepatitis C virus, Varnholt et al. [61] found 29 differentially expressed miRNAs compared to normal liver, but minimal overlap was found between this study and others.
The fusion protein overcomes the inability of FeSOD to permeate the cell membrane, exhibits synergistic apoptotic effects on K562 and HL-60 cells and demonstrates minimal toxicity to normal T cells and the normal liver cell line LO2, indicating its potential value for the treatment of leukemia.
However, the normal liver cell line L-02 showed minimal CPEs after MV-CEA infection.
Histological examination showed a normal liver architecture with mild mixed inflammatory infiltrate and minimal portal fibrosis.
Whereas in the normal liver, most of the uptake was accounted for by blood pool content as demonstrated by minimal increase in the organ-to-blood-pool ratio.
The normal liver may be slightly tender.
