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The minimal models was solved using Gear's method [ 36].
The nonlinear system of equations of 1 D and 2 D minimal models was integrated using the MGSModeller software package [ 35].
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The intuition is that preferred or minimal models are those that maximize typical instances of concepts.
Reasoning with minimal models is at the heart of many knowledge-representation systems.
Minimal models were obtained, and included no quadratics.
The oral and C-peptide minimal models were utilized as before.
To gain a more realistic view of glucose dynamics, mixed meal and oral glucose minimal models were extended upon IVGTT minimal models by parametrically defining the rate of glucose appearance in the plasma (S24 S26).
Minimal models were re-run following the removal of individuals with inbreeding coefficients of 0.25 to check if effects were being driven by individuals with high levels of inbreeding.
Glucose, insulin, and C-peptide concentrations measured before and after ingestion of a mixed meal on day 9 and analyzed using the oral and C-peptide minimal models are the subject of the current report.
The comparison between the assessment of SI using the glucose clamp technique (S11) and minimal models is discussed by Bergman et al. The structural simplicity and ability to evaluate significant physiological parameters has led to more than 1,000 publications related to minimal model.
As for the previously published method [ 6] there is a guarantee through mathematical proof that the list of provided minimal models is complete, in that no possible alternative Petri net is missing that might also be able to explain the data [ 13].
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