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The first is that of a minimal metabolic network.
We define a minimal metabolic network as a network where not a single reaction can be removed without destroying viability.
A minimal metabolic network is a network in which all reactions are essential and none can be removed without rendering it inviable.
In our analysis of random minimal metabolic network viable on the same sulfur sources, we found that such networks can have large genotype distance.
The number of superessential reactions R SE increases with S, but it is generally much lower than the total number of reactions in a minimal metabolic network.
To generate a (random) minimal metabolic network we used the same procedure until no reactions could be removed without destroying viability.
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Another analysis focusing on network sizes is our characterization of minimal metabolic networks, networks in which all reactions are essential.
The figure demonstrates that, first, random minimal metabolic networks can be very different from one another.
We generated 1000 random minimal metabolic networks viable on a given number S of sulfur sources (see methods).
Bacterial symbionts often have minimal metabolic networks, and are often missing pathways or genes essential for life outside of the host environment.
We called a reaction super-essential if it occurred in all minimal metabolic networks generated under a given set of environmental demands.
More suggestions(14)
minimal neural network
minimal lateral network
minimal metabolic acidosis
minimal metabolic transformation
minimal metabolic cost
minimal metabolic signature
minimal connecting network
minimal metabolic derangement
minimal metabolic perturbation
minimal metabolic shift
minimal metabolic rate
minimal metabolic turnover
minimal metabolic activity
minimal metabolic functionality
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