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Identifying minimal mechanisms sufficient to reproduce mechanical influences on cellular structure has important implications in a diversity of fields, including biology, physics, medicine, computer science, and engineering.
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In the proposed minimal mechanism for MAL of Clostridium tetanomorphum, Lys-331 acts as the (S -specific baS -specific and abaseacatalyst3S-proton from l-threo-3-methylandabstractsesultheg in an enolate anion intermediate.
The goal of our mathematical modeling is to seek a simplest or minimal mechanism to mimic the three response patterns shown by biological neurons, rather than giving a detailed biophysical model of spike generation.
The minimal mechanism of DNA synthesis contains three steps.
Thus, the conformational selection model provided a minimal mechanism for binding.
This is a significant achievement and a sobering one too given that it offers a minimal mechanism to a process where only complicated explanations were previously available.
We used transient and steady state kinetics to determine the minimal mechanism for recognition and excision of 1, N-ethenoadenine (εA) by AlkA.
Our findings, as summarized in Table 1, establish that (i) both compounds are noncompetitive inhibitors on GluA1flip and have the same mode of action on GluA1flip that involves a two-step, minimal mechanism of inhibition.
The rate dependencies of the T7 DNAP as a function of dNTPs concentration for dsDNA of increasing GC content were fit to the minimal mechanism shown above to estimate the K 1 values shown in Figure 1G.
Our mathematical model uses a feedback mechanism with similarities to that used in a minimal mechanism explaining activation of Saccharomyces cerevisiae transcriptional activators Msn2 and Msn4 (19) where a shuttling process receives delayed activation from an upstream signal to induce oscillations.
In the generally accepted minimal mechanism, two activators Hunchback (Hb) and Bicoid (Bcd) enable broad permissive eve expression in the region of stripe 2, while two repressors Giant (Gt) and Kruppel (Kr) define the anterior and posterior borders respectively by suppressing eve outside the stripe.
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