45 The hyperinvasive meningococcal strain types that caused the epidemic waves in Norway (ST-32 clonal complex) and the Netherlands ST-41/44 ST-41/44clonalx) seem to have minimal lifespans of 36 and 26 years, respecomplex.
However, should such studies become feasible in the future, then our data would predict that loss of daf-2 would likely have only a minimal effect on lifespan and stress resistance in the gonochoristic species.
A recent study by van Raamsdonk and Hekimi showed that the deletion of all five SOD genes in C. elegans increased levels of oxidative damage but again had minimal effect on lifespan.
Well, the lightbulb supposedly has a 20-year lifespan and uses minimal energy.
Despite being deficient for dystrophin, mdx mice have minimal clinical symptoms and their lifespan is only reduced by ~25% (Fig. 3; Table 1) (Chamberlain et al., 2007; Li et al., 2009).
Mice were fed a diet of either RMH 3000 chow diet (Prolab), or for the CR study, NIH31, in MIT's specific pathogen-free facility, with minimal disease status during the lifespan study.
Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1 +/− mice, suggesting that the beneficial response to DR is dependent on pRb1.
Haplotypes composed of four makers, A433T, G871C, A1050G, and C1177T, three proximal markers adjacent to the structural gene, G871C, A1050G, and C1177T, and two markers with minimal P-values for individual association with lifespan, G871C and C1177T, were significantly associated with lifespan (Table 3, Table S1).
Studies using Queensland fruit flies (Fanson et al., 2009), Mexican fruit flies (Carey et al., 2008), Drosophila melanogaster (Min & Tatar, 2006; Lee et al., 2008; Bruce et al., 2013), and field crickets (Maklakov et al., 2008) show that a low-protein/high-carbohydrate diet is associated with long lifespan; however, the overall caloric intake had minimal effects on lifespan (Mair et al., 2005).
The minimal outlay could be recouped many times over during its lifespan.
