Our global gene expression analysis also revealed a significant upregulation of PCSK2 in minimal invasive FTC compared to FTA.
We performed gene expression analysis of 12 follicular thyroid tumours (4 FTA, 4 minimal invasive FTC and 4 widely invasive FTC) resulting in a list of 25 genes which differed highly in their FTC and FTA expressions.
Moreover we used only genes for further analysis, which were significantly differently regulated in the group of minimal invasive FTC and widely invasive FTC.
We performed global gene expression analysis of 12 follicular thyroid tumours (4 follicular adenomas, 4 minimal invasive follicular carcinomas and 4 widely invasive follicular carcinomas), followed by immunohistochemical staining of 149 cases.
Gene expression analysis was performed using 4 FTA, 4 widely invasive FTC and 4 minimal invasive FTC.
According to the grade of invasion, FTC can be subdivided in widely invasive FTC and minimal invasive FTC.
This is a relevant observation when considering the option of pantethine administration to patients, as muscle analysis could represent the quantitative read-out to evaluate the effect of the compound with a minimal invasive procedure.
Fig. 1 Intraoral photographs of minimal invasive horizontal ridge augmentation using a subperiosteal tunneling technique.
Minimal invasive and simple technique for intrusion, long-term follow-up required.
The biopsies from the healthy volunteers were also used to validate the minimal invasive microbiopsy technique.
