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The presence of overlapping deletions upstream of the FOX cluster in two patients (D9 and D10) with ACD/MPV strongly suggests that critical regulatory sequences are harbored within the minimal interval, and future work will focus on the identification of any evolutionarily conserved elements within this interval and the elucidation of their functional role.
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The minimal interval between stimulation and freezing was ∼20 ms due to the mechanics of the freezing device ('Materials and methods').
The average time period between data collection in the first cohort was four years and two months, with a minimal interval of 3 years and 2 months.
From the selection of 591 putative SNPs mined according to the stringent criteria mentioned above (including a minimal of 12 bases flanking sequence surrounding the target SNP and minimal interval of 12 bases devoid of additional SNPs), 30 SNPs were randomly selected.
This observation is consistent with the minimal interval between foetal infection and birth, which is estimated to be similar for the different ruminant species (three months).
Although four repetitive paracenteses were performed in this study, with a minimal interval of 45 minutes and a maximal of 120 minutes between samples, we did not observe any clinical signs of blood ocular barriers (BOB) breakdown during the sampling period or during the next 24 h, when the cats were examined before reposition to the research colony.
Each administration was initiated by patient request and a minimal interval of one hour was required between administration of first and second line agents.
In our study, the minimal interval between the last surgery and clinical visiting were 3 months, and we thought it is reasonable to eradicate the immediate influence of serum AMH level after ovarian surgery.
This procedure was repeated twice, and the minimal interval between scented solution periods was five days.
To investigate the relationship between the number of putative SNPs and SNP mining parameters, SNPs were mined under different parameter settings regarding the minimal available sequence information flanking the target SNP (1, 2, 3, 4, 6 or 12 bases), and the minimal interval of flanking sequence that must be devoid of additional SNPs (1, 2, 3, 4, 6 or 12 bases).
Each administration was initiated by patient request and a minimal interval of ten minutes was required between of each morphine bolus.
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