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In contrast, areas of bone ingrowth into the polymer scaffold were characterized by minimal inflammatory response and polymer degradation.
Scaffold architecture was modified to enhance cell infiltration leading to revascularization of the islets with minimal inflammatory response.
Bone healing and minimal inflammatory response adjacent to ProRoot and PC implants were observed in both experimental periods, suggesting that both materials are well tolerated.
Cytocompatibility was demonstrated among various cell types, and in vivo biocompatibility test showed minimal inflammatory response within 12 weeks' subcutaneous implantation in mice.
The efficient biocompatibility, minimal inflammatory response to host tissue, relative slow biodegradation rates compared with other materials, and easy availability from sericulture industry make the silk fibroin a desirable candidate for various medical applications [4].
Optimization of these parameters leads to the survival of encapsulated myogenic cells at high density for several months, with minimal inflammatory response and dense neovascularization in the adjacent host tissue.
Similar(39)
Other catechol-modified polymeric adhesives have also been demonstrated to elicit minimal inflammatory responses in vivo.
However, other gram negative pathogenic bacteria (e.g. L. intracellularis and C. rodentium) are able to promote enterocyte proliferation with minimal inflammatory responses [ 4, 5].
None of the treatment groups showed any PMNs and the lymphocyte numbers were negligible in the BAL fluid, indicating minimal inflammatory responses due to the graphene oxide exposure.
Previous studies of gene therapy using AAV have also proven its safety and ability to elicit minimal inflammatory responses in comparison with other types of gene delivery agents [ 17- 20].
hepaticus infection or anti IL-10R alone) elicited minimal inflammatory responses, the combination of H. hepaticus infection with anti-IL-10R antibody administration elicited severe typhlocolitis, with equivalent levels of intestinal inflammation observed in both B6 WT and B6.TLR2−/− mice (Fig. 4).
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