Although it has been well established that Alu subfamilies greater than 20 Myr old can still have active members (Johanning et al. 2003; Salem et al. 2005), our findings suggest that in vivo retrotransposition of AluS is minimal in humans.
In this study, we further analyzed minimal introns in human and mouse genomes.
Hence, it is likely that AKAP7δ is of minimal significance in human AKAP7-mediated PKA signaling.
The authors' documentation of only a minimal radiosensitization in human noncycling fibroblasts upon treatment with PCI-24781 therefore is not very convincing and requires further evaluation.
In addition, we evaluated human tau expression biochemically to provide an indication of the level of variability, and we observed minimal variation in human tau levels throughout the AAV1-TauP301L cohort (Supplementary Material, Fig. S1a).
Like ART, CQ is also an anti-malarial drug that has been suggested to display some cytotoxic activity, although CQ alone only shows minimal toxicity in human primary schwannoma cells.
Therefore, we hypothesized that once reservoir pressure is taken into account, the magnitude of reflections would be minimal in the human aorta.
Despite the minimal data in humans, leflunomide has been assigned an FDA pregnancy category X.
In summary, CUL4A directly regulates processes that are relevant to tumorigenesis, and is more highly expressed in a number of cancers; loss of CUL4A expression is predicted to have minimal effects in humans.
