This compound is an inducer of protein kinase C activity which stimulates HIV-1 expression in latently-infected lymphoid and myeloid cell lines and primary cells [22], [23], [24], [25], [26], [27], [28], [29] with minimal effects on the immune system [26] and causing minimal cell cycle progression [26], [29].
When the bacterial load is below the minimal infecting dose, the immune system is effective in killing bacteria and the patient does not develop an infection.
Following minimal stimulation of the immune system by early intervention, boosting of the established immune response can be achieved by environmental exposure.
Zebrafish mutant models therefore provide the possibility to study functions of the innate immune system with minimal interference of adaptive immunity (at embryo and larval stages).
Reasons may be an insufficient immune defence that lowers the minimal infective dose, as the immune system has not yet fully developed.
Another exciting area, yet to be fully exploited, is the effect of the immune system in the minimal residual disease setting and the role of the immunomodulatory drugs may prove to be of particular interest in this situation.
My health became patchy as the years of minimal sleep and constant stress depressed my immune system.
We want to identify key processes resulting in the observed phenomenon by a restriction to a minimal model representing the dynamics of the immune system and HIV [ 19].
Regulation of adaptive immune responses is critically important to allow the adaptive immune system to eradicate infections while causing minimal collateral damage to infected tissues, as well as preventing autoimmune disease mediated by self-reactive lymphocytes.
As demonstrated recently, priming of the plant's innate immune system confers broad-spectrum resistance with minimal impact on seed set and plant growth [ 15].
