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The key point for successful tissue regeneration includes the use of cells/biomaterials that elucidate minimal immune response after implantation.
When RAW 246.7 cells were grown on the films of insoluble cyanophycin for 96 h, nitric oxide concentration released from the macrophages was below 2 mM/mg protein, suggesting that a minimal immune response was elicited.
In this study, we demonstrated that efficient gene expression within bone is simply achieved by an intramuscular vector injection with a minimal immune response allowing repeated administrations.
Overall these results suggested minimal immune response against GFP-expressing cells.
Asymptomatic UTI was characterized by a minimal immune response that was predominantly monocytic and lymphocytic and was accompanied by a significantly high rate of kidney infection.
In an ideal situation, encapsulated allogeneic or xenogenic islets would have long-term survival with minimal immune response and no requirement for immunosuppression.
Similar(52)
Thus, viral and bacterial infections of the genital tract or intravaginal immunizations induce, in the absence of mucosal adjuvants, minimal immune responses.
Comparable adoptive transfer studies are needed to identify the minimal immune responses elicited by attenuated vaccines that control pathogenic SIV replication.
Partially or completely human antibodies are of particular interest as they are expected to elicit no or minimal immune responses when administered to patients.
The patient had no immune system disease, thus the minimal immune responses might be due to the early and sustained application of glucocorticoid, which has a side effect of repressing immune functions [ 8]; clinical physicians should take note of this finding.
Liposome-mediated DNA delivery exhibits high in vivo transfection efficiency and minimal systemic immune response, thereby allowing for repetitive interventions.
More suggestions(15)
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