The ideal parameter should be sensitive enough to perceive the presence of pathogens with a minimal host response and at the same time specific enough to distinguish between infectious and non-infectious systemic inflammatory response.
An ideal marker of sepsis should be present early in the course of the disease, measurable rapidly and easily, of prognostic significance, sensitive enough to detect infection in patients with minimal host response, and specific enough to discriminate infection from other non-infectious SIRS [ 43].
According to the authors, this may reflect a minimal host immune response to MG infection in the vaginal epithelium, and thus greater bacterial survival in the vagina compared to the endocervix, where the inflammatory response to MG by endocervical epithelial cells is more robust.
One of the most promising advancements in Ad gene therapy is the development of helper-dependent Ad vectors, which have maximal cloning capacity, because all of the viral genes have been removed and would be expected to induce a minimal host-immune response.
Some areas of the genome have minimal host interactions, whereas other regions strongly interact with the innate and adaptive elements of the host immune response.
More importantly, <15% of all detected proteins were found to be of host origin, thereby suggesting minimal host contamination.
Microorganisms which bind to the host cell targets promoting host responses cause these diseases [1, 2].
New pandemic strains are characterized by minimal host immunity.
Many metronomic chemotherapy regimens produce minimal host toxicity and can be given over extended periods.
Nonetheless, the evidence presented in this report, including assessments of vascular permeability and leukocyte infiltration, indicates that any host response is minimal.
