Heterogeneity across functional domains of the same gene were observed in SP14D1 (3 tests) and GNBP (2 tests), whereas differentiation in gambicin was minimal across its functional regions.
These results indicate that the entire A/T-rich region is the minimal functional unit of pbcen5 necessary to permit efficient segregation and maintenance of plasmids during asexual blood-stage mitosis.
The higher pairwise substitution distances and variability identified within the N-terminal region (Fig. 6B) is consistent with this region being subject to minimal functional constraint, further suggesting that these variants may be coding variants without phenotypic consequences.
We suggest that segregating nonframeshifting indels in disordered regions are largely neutral, allowing these regions to change their size with minimal functional consequences.
Under scenario (ii) all species are functionally similar resulting in minimal functional complementarity and maximal functional redundancy.
In general, ABC permeases show the highest level of sequence similarity over the C-terminal five transmembrane regions, and this is considered to be the minimal functional unit [ 11].
It was therefore of interest to determine the context of this 18S rRNA complementary region within the global RNA secondary structure of the minimal functional sequence, and to compare the structure with that determined for the influenza BM2 signal [19].
In vivo analysis of regional function and perfusion defined three regions: the scar, the myocardium adjacent to the scar (MIadjacent, reduced function, reduced perfusion reserve), and the remote myocardium (MIremote, minimal functional deficit, maintained perfusion).
In an attempt to define a "minimal functional unit" within the pbcen5 centromere, we analyzed the maintenance of plasmids that contained either only the regions containing repetitive elements or the core sequence.
E. coli oriC spans the minimal functional 245-bp sequence comprising two parts, the AT-rich DNA unwinding element (DUE) and the DnaA-binding region (Bramhill & Kornberg 1988).
