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The funnel hypothesis can be quantified using energy landscape theory based on the minimal frustration principle.
The principle of minimal frustration predicts that the unfolded ensemble is biased toward productive regions in the conformational space determined by the native structure.
The chapter discusses the lattice and off-lattice models that have played a central role in verifying the general ideas associated with minimal frustration and the protein folding funnel.
We have recently shown that binding mechanisms are robust and owing to the minimal frustration principle, just as for protein folding, are governed primarily by the protein's native topology, which is characterized by the network of non-covalent residue residue interactions.
It is compatible with the robustness of protein structures to mutation described by the notion of minimal frustration [48].
It is also postulated that the sequence of the polypeptide has evolved such that the folding pathways offer minimal frustration [5], [6].
Similar(52)
That began two seasons of two-way frustration and minimal production.
Compared with a restaurant, the frustrations and annoyances are minimal, the food is as good or better-tasting, unquestionably healthier and more environmentally friendly, and much less expensive.
But even sympathetic journalists have expressed some frustration with the Corbyn camp's unwillingness to establish a minimal working arrangement with the media.
Then, to the unit's frustration, it was sent out to Kharbardan, in a dust-bowl district of minimal strategic consequence.
"Minimal, minimal torture".
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